Los Angeles, California - The reigning Super Bowl champions will kick off the NFL season in Thursday night's primetime slot on September 8, as the Los Angeles Rams host this season's Super Bowl favorites, the Buffalo Bills.

There will be plenty of the Rams in this season's marquee time slots as the full 2022-23 schedule was released on Thursday, including a Monday night fixture against the Green Bay Packers in Week 15, and a Christmas Day game against Russell Wilson's Denver Broncos six days later.

The Broncos will not have to wait long for their first eyebrow-raising matchup, travelling to take on Wilson's former team, the Seattle Seahawks, in the first Monday night fixture of the season.

Week 1's third primetime game sees Tom Brady's Tampa Bay Buccaneers heading to "Jerry World" to take on the Dallas Cowboys.

Patrick Mahomes – the man with the richest contract in the sport – will get his first primetime appearance of the season in Week 2's Thursday night showdown, as his Kansas City Chiefs host arguably Mahomes' only competition for best young quarterback, taking on Justin Herbert and the Los Angeles Chargers.

Four-time MVP Aaron Rodgers gets the Sunday night fixture in Week 2 against the Packers' long-time rivals as the Chicago Bears come to town, and his Week 3 matchup against Brady's Bucs will be must-see TV.

The Rams have the toughest strength-of-schedule based on their opponents' 2021-22 records (164-125, .567 winning percentage), while the Cowboys and the Washington Commanders are tied for the easiest schedule (133-155-1, .462 winning percentage).

Meanwhile, the Detroit Lions will be the only team in NFL this season to not have a primetime game.

• Buffalo Bills at Los Angeles Rams (Thursday, September 8)
• New England Patriots at Miami Dolphins (Sunday, September 11)
• Baltimore Ravens at New York Jets
• Cleveland Browns at Carolina Panthers
• Philadelphia Eagles at Detroit Lions
• Pittsburgh Steelers at Cincinnati Bengals
• Jacksonville Jaguars at Washington Commanders
• San Francisco 49ers at Chicago Bears
• Indianapolis Colts at Houston Texans
• Green Bay Packers at Minnesota Vikings
• Las Vegas Raiders at Los Angeles Chargers
• Kansas City Chiefs at Arizona Cardinals
• New Orleans Saints at Atlanta Falcons (afternoon)
• New York Giants at Tennessee Titans (late afternoon)
• Tampa Bay Buccaneers at Dallas Cowboys (night)
• Denver Broncos at Seattle Seahawks (Monday, September 12)

The NFL preseason kicks off on August 4 with the Jaguars taking on the Raiders.