Glendale, Arizona - A disappointing NFL season for the Arizona Cardinals took another turn on Wednesday with general manager Steve Keim taking an indefinite, health-related leave of absence from the team.

Keim is in his 10th year as the Cardinals' GM and has been with the team in some capacity since 1999, when he was hired as a regional scout.

He was signed to a contract extension through 2027 in March after Arizona finished last season 11-6 before a wild card loss to the eventual champion Los Angeles Rams.

"Out of respect for privacy - which is required by law - the team will refrain from commenting further," the Cardinals said in a statement.

Keim's duties will be handled on an interim basis by VP of Personnel Quentin Harris and VP of Pro Personnel Adrian Wilson.

At 4-9, the Cardinals will miss the playoffs for the sixth time in seven seasons, and will remain without a postseason victory since 2016.

Star quarterback Kyler Murray was lost to an ACL tear in Monday night's defeat to the New England Patriots and is expected to have surgery after Christmas.

In 2018, Keim was suspended for five weeks and fined $200,000 by the team following a guilty plea to extreme DUI.