San Clara, California - Trey Lance’s first season as the San Francisco 49ers' starting quarterback is over after only two NFL games after the 2021 number three overall pick fractured his right ankle in Sunday's win over the Seattle Seahawks.

Lance's right leg bent awkwardly when tackled by two Seattle defenders on a designed run on the 49ers' second drive of the game. He was carted off after having his leg placed in an air cast and quickly ruled out of the contest.

Niners head coach Kyle Shanahan confirmed the fracture following his team's 27-7 victory and announced Lance is set to undergo surgery Monday.

"It's always tough, especially when it's a big one like that," Shanahan said. "It's a very sad moment, but you don't have time to sit there and think about it."

"We were real happy about the win, but it was a little somber once you got in the locker room and you see him."

Lance spent his rookie season as the backup to veteran athlete Jimmy Garoppolo but was declared the team's starter this offseason.

The 22-year-old did struggle in last week's 19-10 road loss to the Chicago Bears, completing just 13 of 28 passes for 164 yards and an interception in a game played in rain-soaked conditions.

Garoppolo replaced Lance in Sunday's win and threw for 154 yards and a touchdown with no turnovers on 13-of-21 passing.

"I thought he did a real good job coming off the bench, made some real key throws," Shanahan said. "I'm real proud of Jimmy and how he came in and was ready for the moment and helped us get a win."

Garoppolo did not practice at all during training camp as he recovered from shoulder surgery and spent the summer the subject of trade rumors. The nine-year veteran ultimately remained with the 49ers on a reworked contract that slashed his 2022 salary from $24.2 million to a $6.5-million base, though he can earn close to an additional $9 million in incentives.

The 49ers have had considerable past success with Garoppolo at the helm, as he owns a 31-14 record in 45 regular-season starts since joining the team in a trade with the New England Patriots during the 2017 season.

Garoppolo helped San Francisco reach the Super Bowl during the 2019 season and led the 49ers to last season's NFC Championship Game. The 30-year-old threw for 3,810 yards and 20 touchdowns with 12 interceptions in 15 starts in 2021.