Washington DC - A combative Kamala Harris pledged a clean break from Joe Biden's presidency Wednesday in a fiery interview with right-wing Fox News as she sought to reach Republican voters wary of Donald Trump.

Harris clashed with interviewer Bret Baier on hot-button issues including immigration, with the Democratic nominee repeatedly asking to be allowed to complete her answers.

"May I finish responding?" Vice President Harris at one point said to Baier, regarded as a tough but fair interviewer, in an encounter broadcast from the battleground state of Pennsylvania.

Pressed on previous comments when she said she could not think of anything she would have done differently from Biden, Harris replied, "My presidency will not be a continuation of Joe Biden's presidency."

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"I will bring my life experiences, my professional experiences, and fresh and new ideas. I represent a new generation of leadership," added 59-year-old Harris, who became her party's nominee after the aging Biden dropped out in July.

Biden had said on Tuesday that Harris would "cut her own path" as president.

Harris also launched into a blistering attack on Republican former president Trump (78) for threatening to use the military against internal enemies.

"He's the one who tends to demean and belittle and diminish the American people. He's the one who talks about an enemy within."

The Democrat faced probing questioning during the interview, during which Fox News played an advertisement for Trump about operations for transgender prisoners, and a clip of Trump defending his military remarks.

Her first-ever sitdown with Fox was a gamble as she seeks to break the deadlock in a White House race that remains neck-and-neck with less than three weeks to go.

Fox News has played a key role in Trump's political rise, and he earlier blasted the network over the Harris interview, accusing Baier of being "very soft."

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Trump's campaign later described it as a "train wreck."

"Kamala was angry, defensive, and once again abdicated any responsibility for the problems Americans are facing," Trump spokeswoman Karoline Leavitt said in a statement.

Trump also sat down with Fox News ahead of Harris's appearance, in a pre-recorded town hall with an all-female audience, where the conversation turned to in vitro fertilization (IVF), a fertility treatment that Democrats say is threatened by his policies.

Despite being on home turf, it was a challenging topic as women have been turned off by Trump's statements on reproductive rights, and by his campaign more broadly.

He was cheered as he told his audience in the swing state of Georgia that Republicans were the party championing the procedure.

"I want to talk about IVF. I'm the father of IVF, so I want to hear this question," he said.

Harris, who has made the defense of reproductive rights a centerpiece of her election platform, called his comments "bizarre."

Reproductive rights have been a major vulnerability for Trump since the Supreme Court, featuring three Trump-picked justices, gutted federal protections for abortion access in 2022.

Many in the anti-abortion movement also want to see IVF curbed.

Trump's town hall in Georgia was filmed on Tuesday, the first day of early voting in the closely watched state, with voters casting a record number of 328,000 ballots.

Trump has been charged with election tampering in the state, allegedly pushing for Georgia officials to "find" enough votes to overturn Biden's narrow win there in 2020.