Los Angeles, California - Another shake-up is coming to Grey-Sloan Memorial Hospital! Jesse Williams, who plays Dr. Jackson Avery, is leaving Grey's Anatomy after 12 seasons.

On Thursday, the actor revealed to People that he is officially exiting the long-running medical drama after ten years.

Williams first appeared on the show during season 6, when his character's hospital, Mercy West, merged with Sloan Memorial, previously Seattle Grace.

"I will forever be grateful for the boundless opportunities provided me by Shonda, the network, studio, fellow castmates, our incredible crew, Krista, Ellen, and Debbie. As an actor, director and person, I have been obscenely lucky to learn so much from so many and I thank our beautiful fans, who breathe so much energy and appreciation into our shared worlds," Williams shared.

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He was involved in several pivotal storylines throughout his time on the show, including Avery's romance with April Kepner, played by Sarah Drew.

"The experience and endurance born of creating nearly 300 hours of leading global television is a gift I'll carry always. I am immensely proud of our work, our impact, and to be moving forward with so many tools, opportunities, allies, and dear friends," Williams added.

In April, it was announced that Sarah Drew will be returning to the medical drama on May 20th, which happens to be the same day Jesse Williams will make his exit. Since April and Jackson are long overdue for a reunion, it'll be interesting to see how their story will end.

Williams isn't the first star to make a shocking exit from the series. Patrick Dempsey, Eric Dane, Chyler Leigh, and Katherine Heigl are some of the original cast members who have also left the series. Ellen Pompeo, the show's lead, has also recently made noises about a possible end to her run being in sight.

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Grey's Anatomy is currently on its 18th season and airs Thursdays on ABC.