New York, New York - The official trailer for the next Scream movie, Scream VI, shows Ghostface once again terrorizing Wednesday star Jenna Ortega, but now, in a new city!

Ghostface is back and he's heading to the Big Apple.

The Scream saga continues with its sixth installment that looks to be bigger, bloodier, and dare we say it, scarier!

In the two-minute trailer that dropped on Thursday, Ortega's character Tara and her older half-sister Sam, reprised by Melissa Barrera, are once again being hunted down by the masked killer who taunts that he's a "different" Ghostface.

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As the stalker is seen jumping over furniture and smashing through walls to catch his prey, one thing has definitely changed - he's running rampant through New York City this time.

Also returning to the horror flick are alums Courteney Cox and Hayden Panettiere, who will reprise their roles as Gale Weathers and Kirby, respectively.

Yet this will be the first Scream film that won't feature Neve Campbell's Sidney Prescott. It will be interesting to see how the horror franchise fares without its iconic leading lady, as the new trailer teases that Ghostface's victims are going to need a lot of help.

Who will survive? Who's behind the mask this time? Find out on March 10 when Scream VI hits theaters.