Los Angeles, California - Madonna got brutally honest while answering 50 burning questions from fans.

The 64-year-old pop star dished on the secret behind her successful career and even more iconic lifestyle.

The Vogue singer continued celebrating the release of her Finally Enough Love: 50 Number Ones compilation with raw answers to fans' most burning questions about all things Madonna.

From Britney Spears to her biggest regrets, nothing was off the table in the six-minute YouTube clip.

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When asked what's her current guilty pleasure, the singer boldly declared that sex is always at the forefront of her mind and is what keeps her going. Madonna's openness when it comes to sexuality is no secret, and a later response to a question about her favorite snack was perfectly on brand: "I can't remember his name, oh no! Big d***!"

On the other hand, her biggest regret is letting herself get tied down twice. Madonna was married to fellow actor Sean Penn from 1985 to 1989, and to Guy Ritchie from 2000 to 2008.

The Like A Virgin singer was also asked if another musical collaboration with Britney was in the works, to which she happily responded: "I'm gagging to work with Britney again."

As for what her motto for life is, Madonna simply replied, "Don't f*** with the queen."

Madonna's remix album, which dropped on August 19, features her 50 tracks that topped the Billboard’s Dance Club Songs chart.