Kiawah Island, South Carolina - First Lady Jill Biden is out of isolation after testing negative twice from Covid-19, her office said Sunday.

Biden (71) first tested positive Tuesday while vacationing with her family in South Carolina, and has remained isolated since then.

She has been staying at the vacation home in Kiawah Island during the period of isolation.

The first lady, who is double-vaccinated and received two boosters, experienced mild "cold-like" symptoms and was treated with Paxlovid.

Now that she has been cleared for travel, Biden will return home to Delaware later Sunday, her spokesperson said.

The Northern Virginia Community College English professor caught the virus just weeks after her husband experienced a Paxlovid rebound after coming out of his own quarantine.

Cases of reinfection are common among some patients who receive the Paxlovid anti-viral treatment.

President Joe Biden arrived in Rehoboth Beach, Delaware, Saturday night, according to the White House.